Watch the full video at https://www.jove.com/v/13404?utm_sour... Explore our full cell biology video textbook at https://www.jove.com/science-educatio... JoVE is the world-leading producer and provider of science videos with a mission to accelerate scientific research and education. Millions of scientists, educators and students across 1500+ High Schools, colleges and universities worldwide use JoVE’s library of 17,000+ videos for teaching, learning and research. JoVE High Schools offers expert-created video textbooks, lab videos, science experiment videos, interactive assessments, and seamless integration into school systems. These comprehensive learning resources help educators tackle teaching challenges, engage students, and meet curriculum requirements, enhancing the high school learning experience. Subscribe to our YouTube Channel - / @jovehighschools Follow us on - Facebook - / jovehighschools Instagram - / jovehighschools Cryo-electron microscopy or cryo-EM examines frozen biological samples at cryogenic temperatures below −150 °C. Unlike conventional EM, cryo-EM does not require fixing and dehydrating a sample which helps to preserve the native state of biological structures. The high-energy electrons used in EM can damage a sample’s chemical bonds.