Regulation of Acid-Base Balance | Reabsorption of HCO3 and Secretion of Hydrogen Ion

Here again, with an exciting Physiology video stuffed with in-depth knowledge. The topic under discussion is the Regulation of Acid-Base Balance. So, bring your pens and paper to note down all the details on the conditions of Acidosis, Alkalosis, and regulation of Acid-Base balance by Kidney. ▬ 📌 Regulation of Acid-Base Balance The kidney plays an important role in the maintenance of acid-base balance by: 🔹Reabsorption of Bicarbonate ions 🔹Secretion of Hydrogen ions ▬ 📌 Reabsorption of Bicarbonate Ions 🔸About 4,320 mEq of bicarbonate is filtered by the glomeruli every day. 🔸Excretion of this much bicarbonate in urine will affect the acid-base balance of body fluids. 🔸Bicarbonate must be taken back from the renal tubule by reabsorption. 🔸Secretion of hydrogen ions Secretion of H+ occurs by two pumps: 🔹Sodium-hydrogen antiport pump 🔹ATP-driven proton pump In the case of hydrogen ions: 📍About 4,380 mEq of hydrogen ions appear every day in the renal tubule by means of filtration and secretion. 📍Out of 4,380 mEq, about 4,280 to 4,330 mEq of hydrogen ions is utilized. ▬ 📌 Acidification of Urine Acid-base balance in the body is maintained by the kidney. The kidney plays an important role in preventing metabolic acidosis by excreting hydrogen ions. Excretion of hydrogen ions occurs by three mechanisms or renal mechanisms for the regulation of acid-base balance: ✧ Bicarbonate Mechanism ✧ Phosphate Mechanism ✧ Ammonia Mechanism ▬ 📌 Disturbance of Acid-Base Status The Acid-Base disturbances are: 🔹Respiratory Acidosis 🔹Respiratory Alkalosis 🔹Metabolic Acidosis 🔹Metabolic Alkalosis ▬ 📌 Metabolic Acidosis Metabolic acidosis is: 🔸Acid-Base Imbalance 🔸Abnormal Metabolic Metabolism 🔸Organic Acids Increase The causes of Metabolic acidosis are: 🔹Circulatory Shock 🔹Diabetes Mellitus 🔹Renal Diseases 🔹Acid Poisoning 🔹Renal tubular acidosis 🔹Diarrhea 🔹Pancreatic, Intestinal, or Biliary Fistula I cannot pen down all their details here, but obviously, I have made all the effort for you in the video. The acid-base balance concept map is well explained in the video along with the Acid-Base balance pathophysiology. So, grab their details there. ▬ 📌 Metabolic Alkalosis Metabolic alkalosis is: 🔸Loss of excess Hydrogen ions 🔸Increased Bicarbonate 🔸Increased pH The causes of Metabolic alkalosis are: 📍Hyperchloremic acidosis 📍Hypoalbuminemia 📍Multiple Myeloma 📍Hyponatremia 📍Renal disease 📍Hyperthyroidism 📍Toxicity So that was all! The rest can be watched in the video. ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻‍⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More