IFNg activated dermal lymphatic vessels restrict anti tumor immunity

Presented By: Amanda Lund, PhD Speaker Biography: Amanda W. Lund, PhD is an Associate Professor in the Ronald O. Perelman Department of Dermatology and Department of Pathology at the NYU Grossman School of Medicine and is a Member of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Health. She received a PhD in Biology from Rensselaer Polytechnic Institute in Troy, New York (2009), and completed Postdoctoral training in cancer immunology with Dr. Melody A. Swartz at the Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Dr. Lund’s early work established the paradigm that tumor-associated lymphatic vessel remodeling plays a role in regulating anti-tumor immunity where lymphatic vessels are both necessary for adaptive immune priming and also contribute to multiple mechanisms of immune resolution and tumor immune escape. Webinar: IFNg-activated dermal lymphatic vessels restrict anti-tumor immunity Webinar Abstract: Mechanisms of immune suppression in peripheral tissues counteract protective immunity to prevent immunopathology and are coopted by tumors for immune escape. While lymphatic vessels facilitate T cell priming through dendritic cell and antigen delivery to lymph nodes, they also exert PD-L1-dependent immune suppressive effects in lymph nodes at steady state, and facilitate melanoma metastasis. How lymphatic vessels may switch between immunogenic and immune suppressive roles remains and area of active investigation. Here we demonstrate a specific role for non-hematopoietic, non-tumor PD-L1, in limiting CD8+ T cell accumulation in melanoma. We find that IFNg produced by tissue infiltrating, antigen-specific CD8+ T cells is sufficient to activate lymphatic vessel PD-L1 expression. As such, disruption of IFNg-dependent crosstalk through lymphatic-specific loss of IFNγR boosts T cell accumulation in melanoma leading to CD8+ T cell-mediated tumor control and improved overall survival. Earn PACE Credits: 1. Make sure you’re a registered member of LabRoots https://www.labroots.com/virtual-even... 2. Watch the webinar on YouTube or on the LabRoots Website https://www.labroots.com/webinar/ifng... 3. Click Here to get your PACE credits (Expiration date – June 02, 2023 ): https://www.labroots.com/credit/pace-... LabRoots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc