This session covers a wide range of epidemiological and health outcomes-based research in cystic fibrosis, including both population-level and patient-level analyses. Topics covered include regression analyses assessing patterns in patient-level lung function; associations between environmental exposures and rapid disease progression; the effect of newborn screening in the US; epidemiology and CFTR mutations in the Asian CF population; and international comparison of CF outcomes in Australia, Canada, and France. Originally recorded November 4, 2021.