Hermann Einsele, MD, FRCP, University Hospital of Würzburg, Würzburg, Germany, briefly discusses combinatorial CAR-T approaches being explored in multiple myeloma, and comments on how these strategies may be used to overcome mechanisms of resistance and improve CAR-T cell efficacy. This interview took place at the EBMT-EHA 5th European CAR T-cell Meeting held in Rotterdam, The Netherlands. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.