The RNA-World Paradox! | #EvolutionCourse Session 4

Is RNA World Hypothesis true? The RNA-world hypothesis is widely accepted by evolutionary biologists as a step to account for the development of the complexity seen in DNA based life. We explore why this hypothesis is unviable given available data and observations. === Contents: Is RNA-World Hypothesis Real? Replication and Mutation RNA-world Hypothesis Catalysis for life! RNA autocatalysis: Could RNA have just replicated itself? RNA replication through enzymes? Proteins Ribosomes, Transcription, and Proteins! The minimum genome? How big can RNA be? Kicking the can further? RNA-world 4 Paradoxes === For those who prefer reading: Article concerning the topic on: https://findingtruthchannel.com/cours... === References: Molecular Biology of the Cell. 4th edition: https://www.ncbi.nlm.nih.gov/books/NB... Autocatalytic Networks at the Basis of Life’s Origin and Organization: https://www.ncbi.nlm.nih.gov/pmc/arti... (Def: https://www.merriam-webster.com/dicti... Read: Replication and Expression Strategies of Viruses: https://www.ncbi.nlm.nih.gov/pmc/arti... Selection of an improved RNA polymerase ribozyme with superior extension and fidelity: https://rnajournal.cshlp.org/content/... Further reading with the following two papers, (DOI: 10.1261/rna.548807, DOI: 10.1126/science.1060786) RNA Replicase, Read wiki here: https://en.wikipedia.org/wiki/RNA-dep... Read: Ribosomes - Definition, Structure, Size, Location and Function (microscopemaster.com): https://www.microscopemaster.com/ribo... Read about Ribosomes: https://en.wikipedia.org/wiki/Ribosome Read: Systems Biology Perspectives on Minimal and Simpler Cells: https://www.ncbi.nlm.nih.gov/pmc/arti... Systems Biology Perspectives on Minimal and Simpler Cells: https://www.ncbi.nlm.nih.gov/pmc/arti... Read abstract: The evolution of genome compression and genomic novelty in RNA viruses: https://www.ncbi.nlm.nih.gov/pmc/arti... Read article in nature mag: Discovery of the Giant Mimivirus: https://www.nature.com/scitable/topic... Read: Genomics of Megavirus and the elusive fourth domain of Life: https://www.ncbi.nlm.nih.gov/pmc/arti... Read it here in the abstract of this paper: The evolution of genome compression and genomic novelty in RNA viruses: https://www.ncbi.nlm.nih.gov/pmc/arti... A Pre-RNA World Probably Predates the RNA World: https://www.ncbi.nlm.nih.gov/books/NB... Did Gene Expression Co-evolve with Gene Replication? https://link.springer.com/chapter/10.... === Videos used in the session for educational purposes: From DNA to protein - 3D:    • From DNA to protein - 3D   Six Microseconds of Protein Folding:    • Six Microseconds of Protein Folding   === #RNAWorld #EvolutionCourse Remember to send your questions for the Saturday livestream. Watch and share with loved ones:    • The RNA-World Paradox! | #EvolutionCourse ...