At the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, a panel of multidisciplinary experts convened to discuss non–small cell lung cancer (NSCLC). Moderated by Balazs Halmos, MD, of the Montefiore Einstein Comprehensive Cancer Center, the roundtable featured perspectives from Jay Lee, MD, of the University of California, Los Angeles (UCLA), Mary Pasquinelli, DNP, APRN, FNP-BC, of the University of Illinois Chicago (UIC), and Momen Wahidi, MD, MBA, of Northwestern Medicine. In the final segment of this roundtable discussion, the multidisciplinary panel shares their hopes for the future of NSCLC treatment and surgery, as well as the questions that they would like to see answered in the field.