⚾ MLB Game Picks *Best Bets* for Wednesday, 9/25

What’s up guys, welcome back to Third and Long! Here are my latest MLB game predictions and best bets for Wednesday, September 25th, 2025. We’ll go game-by-game, breaking down every matchup on today’s slate — looking at spreads, moneylines, and over/unders. You’ll get my picks on who will win, who will lose, final score predictions, and how I’m betting each game. We’ll compare lines, find value, and break down the key stats that matter. For even more in-depth analysis, check out my full MLB predictions playlist for daily breakdowns all season long. Thanks for watching. Make sure to subscribe and like. Here's my X/Twitter page, follow along https://x.com/Sports_365_247_ National League East Atlanta Braves Miami Marlins New York Mets Philadelphia Phillies Washington Nationals Central Chicago Cubs Cincinnati Reds Milwaukee Brewers Pittsburgh Pirates St. Louis Cardinals West Arizona Diamondbacks Colorado Rockies Los Angeles Dodgers San Diego Padres San Francisco Giants American League East Baltimore Orioles Boston Red Sox New York Yankees Tampa Bay Rays Toronto Blue Jays Central Chicago White Sox Cleveland Guardians Detroit Tigers Kansas City Royals Minnesota Twins West Houston Astros Los Angeles Angels Oakland Athletics Seattle Mariners Texas Rangers