Victorian Premier Daniel Andrews has acknowledged the hard work, passion and commitment of Jenny Mikakos following her recent resignation as Victorian health minister. Ms Mikakos resigned from her role on Saturday after Premier Andrews recently named her as the person responsible for the state’s hotel quarantine program. Mr Andrews said he has spoken to many of his colleagues following the recent announcement from Ms Mikakos. "No one's happy to see someone whose an incredibly hardworking member of the team go," Mr Andrews said during a press conference on Sunday. "But when you make a decision that you can't serve in the Cabinet, then you can't serve in the Cabinet, you need to tender your resignation, that's exactly what happened". "I wish her well, and I acknowledge her hard work and her passion and her commitment. "To do anything else would be simply wrong." Mr Andrews also said Victorians "can't let our guard down". "We can't pretend this is over because we desperately want it to be".