Warfarin Initiation

This is a video discussing the controversial topic of Warfarin Initiation These are my references: 1. Halford NH. Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship. Clin Pharmacokinet 1986;11(6):483-504 2. O’Reilly RA. Vitamin K and other oral anticoagulant drugs. Annu Rev Med. 1976;27:245-261 3. Kelly JG, O’Malley K. Clinical pharmacokinetics of oral anticoagulants. Clin Pharmacokinet. 1979;4:1-15 4. Lexicomp Online®, Lexi-Drugs® Aspirin, Hudson, Ohio: Lexi-Comp, Inc.; May 29, 2018. 5. Batlouni M. Anticoagulantes orals. In: Batlouni M, Ramires JAF, editors. Farmacologia e terapeutica cardiovascular. 2nd ed. Sao Paulo: Atheneu; 2004. p. 351-620 6. Wells PS, Le Gala G, Tierney S et al. Practical application of the 10-mg warfarin initiation nomogram. Blood Coagul Fibrinolysis. 2009;20:403-408 7. Monkman K, Lazo-Langner A, Kovacs MJ. A 10 mg warfarin initiation nomogram is safe and effective in outpatients starting oral anticoagulant therapy for venous thromboembolism. Thromb Res. 2008;124(3):275-280 8. Quiroz R, Gerhard-Herman M, Kosokowsky JM, et al. Comparison of a single end point to determine optimal initial warfarin dosing (5 mg versus 10 mg) for venous thromboembolism. Am J Cardiol. 2006;98(4):535-537 9. Kovacs MJ, Roger M, Anderson DR, et al. Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. Ann Intern Med. 1997;126(2):133-136 10. Crowther MA, Ginsberg JB, Kearon C et al. A randomized trial comparing 5-mg and 10-mg warfarin loading doses. Arch Intern Med 1999;159:46-48 11. Harrison L, Johnston M, Massicotte P et al. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med. 1997;126:133-136 12. Schulman S, Lockner D, Bergstrom K et al. Intensive initial oral anticoagulation and shorter heparin treatment in deep vein thrombosis. Thromb Haemost. 1984;52(3):276-280 13. Apostolakis S, Sullivan RM, Olshansky B et al. Factors affecting quality of anticoagulantion control among patients with atrial fibrillation on warfarin. Chest 2013;144(5):1555-1563 YouTube Link 1:    • Coagulation Cascade   YouTube Link 2:    • Hemostasis: Lesson 4 - Tests (INR, PTT, pl...