🧬 Molecular Basis of Lysogeny in Lambda Phage

This in-depth academic lecture examines the molecular and genetic regulation of lysogeny in bacteriophage lambda (λ). It explores the precise integration of λ DNA into the E. coli chromosome via site-specific recombination at attP and attB sites, mediated by integrase. Emphasis is placed on the genetic switch that governs the lysis–lysogeny decision, including the intricate interplay of transcriptional regulators cI (lambda repressor), Cro, CII, and CIII, and the environmental cues that influence their expression and stability. We also analyze the maintenance of the prophage state through cI autoregulation, the role of antitermination proteins (N and Q), and the molecular triggers leading to prophage induction under SOS response conditions. This lecture is ideal for advanced students and researchers in molecular microbiology and bacteriophage genetics. #LambdaPhage #Lysogeny #GeneRegulation #BacteriophageGenetics #MolecularMicrobiology #cIcroSwitch #LyticLysogenicDecision #SOSResponse For more details watch the video ‪@microbiologywithdr.sunitab7480‬​