A patient with sickle cell trait inherits one normal hemoglobin gene and one sickle gene —

Sickle cell trait? Not full-blown sickle cell disease — but not totally innocent either 😏 The most common complication isn’t pain crisis — it’s hematuria, thanks to renal papillary necrosis! Add a little polyuria + nocturia to the mix — classic carrier consequences 💉🧬 ⸻ 📦 Description A patient with sickle cell trait inherits one normal hemoglobin gene and one sickle gene — a carrier state of this autosomal recessive disorder. Though usually asymptomatic, the most common complication is hematuria, often due to renal papillary necrosis. 🔹 Mechanism: Sickling in the renal medulla causes ischemia → necrosis → hematuria 🔹 Associated symptoms: Polyuria, nocturia 🔹 Trigger factors: Dehydration, high altitude, strenuous exercise Remember — sickle cell trait ≠ disease, but it still comes with kidney drama 🚨 Hashtags #SickleCellTrait #Hematuria #Polyuria #Nocturia #RenalPapillaryNecrosis #Hematology #Genetics #AutosomalRecessive #CarrierState #MedStudent #MedEd #USMLE #StepPrep #DoctorLife #ClinicalPearls #MedicineSimplified #Pathophysiology #HemeOnc #Nephrology #SickleCell