Webinar: Investigating Targeted CD3 Activation in Cytotoxic T cells via Immune Checkpoint Inhibition

Webinar with The Scientist and Dr. Kristin Fino of the Frederick National Laboratory for Cancer Research Immune checkpoint inhibitors promote anti-tumor immune responses by enhancing T-cell activity. Measuring the pharmacodynamic effects of these drug types presents a challenge as both the immune and cancer cell populations must be separated and assessed individually. Using a quantitative multiplex immunofluorescence assay (mIF) allows for in-depth cell phenotype characterization and spatial context. Researchers at Frederick National Laboratory for Cancer Research developed a robust mIF assay with InSituPlex® technology to better investigate T-cell activation states within the tumor microenvironment and across multiple patient tumor biopsies. In this webinar, Dr. Kristin Fino of the Frederick National Laboratory will present the obstacles associated with developing biomarker strategies and a multiplex immunofluorescence solution that improved the assessment of tumor-immune interactions. Topics Covered: Introduction to the InSItuPlex® technology Development of a multiplex panel for the quantitative assessment of T-cell activation in relation to tumor cells Analyzing biomarker and cell phenotype trends across tumor types