Aubrey de Grey: Reaching longevity escape velocity | Curing aging | Beyond Podcast w Javier Ideami

This episode explores how medical technology can help humans in reaching longevity escape velocity, curing aging with medical technology and repairing the 7 kinds of damage it produces. Aubrey de Grey is a biomedical gerontologist, Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today not to die from age-related causes. Aubrey is also an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies. Support this channel by exploring our projects: Interactive Clothing and Design: https://posterini.com Brainstorming platform: https://torch4ideas.com Advanced A.I Visualizations: https://losslandscape.com EPISODE LINKS: Sense Research Foundation: https://www.sens.org/ Ending Aging: https://www.amazon.com/Ending-Aging-R... Twitter:   / aubreydegrey   Wikipedia: https://en.wikipedia.org/wiki/Aubrey_... INFO: Podcast website: https://volandino.com Spotify: https://open.spotify.com/show/3O74ctu... Apple Podcasts: https://podcasts.apple.com/us/podcast... Full episodes playlist:    • The Beyond Podcast   OUTLINE: 00:00 - Intro 01:54 – The 7 kinds of damage that produce aging 05:13 – Loss of cells and stem cell therapy 07:00 – Waste products inside cells – arteriosclerosis and macular degeneration 08:36 – Waste products outside cells – phagocytosis by inmune stimulation 09:20 – Cells dividing when they are not supposed to. Nuclear mutations, cancer, inmunotherapy, telomerase/ALT gene deletion plus periodic stem cell reseeding 09:45 – Death resistant cells: making space for new cells, senescent cells, gene therapy 10:57 – Accumulation of mutations in the Mitochondria, backup copies of the DNA, allotopic expression of the 13 proteins 11:50 – Elasticity, major arteries: AGE-breaking molecules/enzymes 13:15 – Engineered negligible senescence: an engineering approach to fixing aging 14:25 – How much we don’t need to know: Pioneering technologist vs basic scientist mindset 16:17 – Reaching the fundamental understanding – nearly 40 years ago 17:23 – Adapting existing theories to the field of aging, bringing together ideas from other fields. 20:44 – Using soil bacteria to degrade long-lived organic material: bringing ideas from the environmental decontamination field to the field of aging 21:57 – Vulcanization of science: bias against cross-disciplinary work 22:54 – Being an outlier 23:37 – From programming to leading the fight against aging 25:26 – Backups of genes and the key 13 proteins of the Mitochondria 26:23 – What is different and what is similar in the way different species age? 27:25 – Caenorhabditis elegans worm aging vs human aging 28:33 – Tortoises, shellfish vs warm blooded organisms 29:14 – Studying organisms closer to us in evolutionary terms: mammals 29:35 – The Pro aging argument: desirability vs viability 30:18 – The 50-50 chances of living indefinitely for those in middle age today 31:30 – The storytelling argument vs exploring novelty and diversity 33:20 – The pro-aging trance: a psychological coping mechanism 34:30 – The boredom argument: alzheimer at 80 vs bored at 150 34:59 – Overpopulation: technology increasing the carrying capacity of the planet – Renewable energy, artificial meat, desalination, bacteria that eat plastic, etc 37:14 – Perception of risk: self-driving cars and the lowering of risks brought by technology 39:45 – Today’s pensions vs economic benefits of improvements in longevity 40:57 – Work & automation: developing a new attitude in life 41:45 – Longevity: attitude and motivations 43:44 – AGI – artificial intelligence – the artificial researcher – machine learning and drug discovery, impact on aging research 45:17 – Fixing aging in the brain vs the rest of the body 46:44 – Regulation and politics: the quick switch, the urgent need to develop anti-aging policies 51:14 – Nanobots and Xenobots: the utility of non-biological solutions to medical problems 53:14 – SENS Foundation and how to go faster 55:50 – Challenges ahead 57:05 – Making a difference in the world CONNECT: Subscribe to this YouTube channel Ideami's Twitter:   / ideami   Volandino's Twitter:   / volandinospace   Ideami's LinkedIn:   / ideami   ideami's Facebook:   / javierideami   Instagram:   / javierideami   Medium:   / ideami   Support on Patreon:   / ideami