Virology 2014 lecture #18 - Transformation and oncogenesis

The story of how transformation and oncogenesis caused by RNA and DNA tumor viruses is a fascinating account that lead to our understanding of how the cell cycle is controlled. In this lecture we talk about how retroviruses and DNA viruses transform cells, including oncogene capture and activation, and interference with the cell cycle via Rb and p53 proteins. It all begins with Peyton Rous and a chicken with a tumor.