New city, new rules: In the latest installment of the legendary horror franchise, the four survivors of the infamous Ghostface killer's recent killing spree leave their hometown of Woodsboro behind to start a new chapter in New York City. But to their horror, there's no escaping the past. Ghostface is determined to carve out a particularly bloody slice of the Big Apple. SCREAM 6 picks up where SCREAM (2022) left off and continues the story of sisters Sam (Melissa Barrera) and Tara (Jenna Ortega), as well as twins Chad (Mason Gooding) and Mindy (Jasmin Savoy Brown). Along with them, the iconic killer Ghostface leaves his trail of blood from the tranquil town of Woodsboro into the skyscraper canyons of New York City. Fans of the series can look forward to seeing legendary characters from the early years again, including Kirby Reed (Hayden Panettiere) and reporter Gale Weathers-Riley (Courteney Cox). The cast is rounded out by newcomers Jack Champion (AVATAR: THE WAY OF WATER, AVENGERS ENDGAME), Henry Czerny (MISSION: IMPOSSIBLE – DEAD RECKONING PART ONE), Liana Liberato (IF I STAY, "Light as a Feather"), Dermot Mulroney (THE RAMBLER), Devyn Nekoda ("Ginny & Georgia," SNEAKERELLA), Tony Revolori (SPIDER-MAN: HOMECOMING), Josh Segarra ("Arrow," "She-Hulk"), and Samara Weaving (READY OR NOT). ``` Matt Bettinelli-Olpin and Tyler Gillett returned to direct, and James Vanderbilt and Guy Busick once again wrote the screenplay. William Sherak, James Vanderbilt, and Paul Neinstein produced the film.