Placental signature identified in early-onset colorectal cancer

Gianluca Mauri, MD, PhD, University of Milan, Milan, Italy, provides an overview of findings from a study, which revealed that early-onset colorectal cancer (EO-CRC) displays molecular reactivation of placental features distinguishing it from standard-onset disease. Proteomic and transcriptomic analyses showed overexpression of placental-associated proteins and HERVH-driven transcriptional activity linked to immune evasion and tumor aggressiveness. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.