Right now pharmacists, doctors and nurses are administering two vaccines Pfizer and Moderna, but there could soon be a third: Johnson & Johnson. Let's start by talking about the number of doses. For Moderna and Pfizer, you have to get two shots for full effectiveness, but for Johnson & Johnson, you'll only need one dose. The second category: what's actually in the vaccine. Pfizer and Moderna use what's called messenger RNA or mRNA. They are proteins that activate an immune response. Johnson & Johnson went down a different path, using dead virus to activate spike proteins and evoke an immune response. Vaccine efficacy. This is the measurement of how well the vaccine performs under ideal conditions. Pfizer showed 95% efficacy and Moderna 94%. Johnson & Johnson had the lowest efficacy rates at 66%. None of these vaccines had been tested on women who were pregnant or breastfeeding and none of them were tested on teenagers or children. Subscribe to Local 5 on YouTube: / weareiowalocal5news Download the We Are Iowa app: https://weareiowa.com/app Get Local 5’s "5 Things to Know" newsletter in your inbox: https://weareiowa.com/email 'Like' Local 5 on Facebook: / weareiowa Follow Local 5 on Twitter: / weareiowa5news Follow Local 5 on Instagram: / weareiowa