Respiratory | Oxygen-Hemoglobin Dissociation Curve

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this respiratory physiology lecture, Professor Zach Murphy provides a clear and high-yield breakdown of the Oxygen-Hemoglobin Dissociation Curve, a critical concept for understanding how oxygen is loaded in the lungs and unloaded in the tissues. We begin by reviewing the S-shaped (sigmoidal) curve, which illustrates the relationship between partial pressure of oxygen (PaO₂) and hemoglobin saturation (SaO₂). You’ll learn why this shape is essential for efficient oxygen uptake in the lungs and controlled oxygen release in peripheral tissues. The lecture then explores the factors that shift the curve: • A right shift (reduced affinity) caused by increased CO₂, acidosis (↓pH), increased temperature, and 2,3-BPG—enhancing oxygen unloading at tissues (Bohr effect) • A left shift (increased affinity) caused by alkalosis (↑pH), hypothermia, low 2,3-BPG, carbon monoxide, and fetal hemoglobin, impairing oxygen release Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #OxygenHemoglobinCurve #Respiratory