Apple cider vinegar is one of the most talked-about natural health tools — but when should you actually take it? Morning, before meals, or before bed? In this powerful 14-minute science-based talk, Dr. David Sinclair explains exactly how apple cider vinegar works inside the body, including its effects on digestion, blood sugar control, fat burning, gut health, and metabolic longevity. You’ll learn: Why apple cider vinegar does not digest food — but activates digestion How it improves insulin sensitivity and stabilizes blood sugar The AMPK fat-burning connection When apple cider vinegar helps (and when it can hurt) The safest and most effective dosage Why timing matters more than quantity This video breaks down the mechanisms, not myths — so you can choose the best timing based on your personal metabolic goals. ⚠️ This is educational content intended to help you make informed lifestyle decisions. ⏱️ Time Stamps (with Emojis) 00:00 🔥 Why Everyone Is Confused About Apple Cider Vinegar 01:12 🧠 The #1 Mistake People Make With ACV 02:05 🧪 How Apple Cider Vinegar Really Works 03:18 🍽️ Digestion & Low Stomach Acid Explained 04:45 🔥 The Acid Reflux Paradox 05:52 🍬 Blood Sugar Control & Insulin Sensitivity 07:10 ⚡ AMPK, Energy & Fat Burning 08:22 🍽️ Best Time: Before Meals 09:45 🌅 Best Time: Morning (Empty Stomach) 11:02 🌙 Best Time: Before Bed (Who Should & Shouldn’t) 12:18 🦷 Tooth, Gut & Safety Considerations 13:10 ✅ Final Recommendation by Dr. Sinclair apple cider vinegar timing, david sinclair apple cider vinegar, best time to take apple cider vinegar, apple cider vinegar before bed, apple cider vinegar blood sugar, apple cider vinegar fat loss, apple cider vinegar digestion, acv insulin sensitivity, acv gut health, apple cider vinegar ampk, longevity supplements, metabolic health, fasting and apple cider vinegar, apple cider vinegar science, apple cider vinegar benefits, david sinclair longevity, blood sugar control natural, apple cider vinegar dosage, gut microbiome health, modern longevity #DavidSinclair, #AppleCiderVinegar, #Longevity, #MetabolicHealth, #BloodSugarControl, #InsulinResistance, #GutHealth, #FatBurning, #AMPK, #HealthOptimization, #AntiAging, #Biohacking, #ModernLongevity, #FastingScience, #NutritionScience, #Wellness, #HealthyHabits, #LifeExtension, #PreventDisease, #ScienceBased 🔍 Top 5 Searches for This Topic Best time to take apple cider vinegar Apple cider vinegar before bed benefits David Sinclair apple cider vinegar Apple cider vinegar for blood sugar Apple cider vinegar fat loss science 📚 Reference Johnston CS et al., Journal of Functional Foods Ostman E et al., European Journal of Clinical Nutrition Hardie DG, AMPK and Metabolic Regulation Harvard Medical School – Nutrition & Metabolism Research Dr. David Sinclair – Longevity & Aging Research (Harvard) ⚠️ Disclaimer This video is for educational and informational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before making changes to your diet, supplements, or health routine, especially if you have a medical condition or take medications.