USF vs. Old Dominion prediction, odds: 2025 Cure Bowl matchup picks by proven model

USF vs. Old Dominion prediction, odds: 2025 Cure Bowl matchup picks by proven model USF vs Old Dominion prediction 2025 2025 Cure Bowl picks Cure Bowl odds & prediction USF vs ODU spread analysis College football bowl predictions USF South Florida Bulls preview Old Dominion Monarchs preview Cure Bowl betting odds Advanced model picks Cure Bowl College football expert picks 2025 USF vs Old Dominion odds explained Best bets 2025 Cure Bowl Spread & moneyline analysis College football betting model Cure Bowl matchup breakdown USF vs ODU game preview 2025 Cure Bowl odds trends NCAA bowl predictions video USF ODU score prediction Proven model betting picks The Old Dominion Monarchs face the South Florida Bulls in the 2025 Cure Bowl on Wednesday. Old Dominion closed the regular season with five consecutive wins, while USF won its last two games and three of four. The Monarchs (9-3), who finished second in the Sun Belt East Division at 6-2, outscored their opponents by 161 points this season. The Bulls (9-3), who finished tied for fourth in the American Conference, outscored their foes by 236 points in 2025. USF quarterback Byrum Brown and Old Dominion quarterback Colton Joseph have both opted out. South Florida coach Alex Golesh and most of the offensive staff will also not coach since Golesh took the Auburn job. #CureBowl2025 #USFvsOldDominion #CollegeFootballPredictions #CFBPicks #BettingOdds