In A Plague Tale: Requiem, players continue the journey of Amicia and her younger brother Hugo, who are searching for a cure for Hugo's mysterious blood disease. The siblings flee from the Inquisition and hordes of rats that spread the plague, traveling through Southern France to find a prophesized island that may hold the key to saving Hugo. The game explores themes of survival, sacrifice, and the bond between siblings in a world ravaged by supernatural forces and war.