Can anxiety cause leg weakness? Jul 4, 2019 Also, since stress hormones are stimulants, a body that is persistently stress response overstimulated can become tired and feel weak. This weakness often is experienced in the limbs, such as the arms and legs. Unfortunately, many anxious personalities worry about their health. ·········· “Our mission is to provide the possible best answers for your questions. The clever ones reach their goal in life. This requires knowledge and accurate answers. We will help you with that.” ✋ We explore this topic from SCIENTIFIC perspective, and we don't want to make judgment. If you think, this answer is doesn't really help or is somehow harmful, please mind, this made with EDUCATIONAL purpose.