6Patterns – Top 25 Pearls of Pulmonary Pathology Series. Max and Kevin discuss how clinical and radiologic information can help refine your diagnosis in interstitial lung disease. This case of Combined pulmonary fibrosis with emphysema (CPFE) highlights the histologic features of smoking related pathology superimposed on a case of UIP of IPF. Topic 3 Pear 3: Combined pulmonary fibrosis with emphysema (CPFE) is a very difficult diagnosis to make pathologically, but makes a lot of sense to clinicians Visit www.6patterns.org for more. Videos are for education and entertainment only and should not be used as medical advice.