17. MEN & MEN-like Syndromes 🧬 USMLE Step 2 CK | Internal Medicine Endocrinology High-Yield Review
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:-https://t.me/conceptualmedicine009 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/conceptual_... MEN & MEN-like Syndromes 🧬 USMLE Step 2 CK | Internal Medicine Endocrinology High-Yield Review This high-yield lecture dives into the world of Multiple Endocrine Neoplasia (MEN) syndromes and related MEN-like disorders — a favorite topic in USMLE Step 2 CK and internal medicine endocrinology. MEN syndromes are inherited disorders characterized by tumors in multiple endocrine glands, and recognizing their distinct combinations, inheritance patterns, and associated gene mutations is essential for solving board-style clinical vignettes involving hypercalcemia, endocrine tumors, catecholamine excess, and gastrointestinal symptoms. 🧠🧪 The video starts by comparing the three classic MEN types: 🧬 MEN Type 1 (Wermer Syndrome) – mutation in the MEN1 gene (tumor suppressor) Involves the “3 Ps”: – Parathyroid hyperplasia → hypercalcemia – Pituitary tumors (often prolactinomas) – Pancreatic neuroendocrine tumors (e.g., gastrinoma, insulinoma) 🧬 MEN Type 2A (Sipple Syndrome) – mutation in the RET proto-oncogene Involves: – Medullary thyroid carcinoma (MTC) – calcitonin-secreting tumor – Pheochromocytoma – catecholamine-producing adrenal tumor – Parathyroid hyperplasia 🧬 MEN Type 2B – also RET mutation, but more aggressive Includes: – Medullary thyroid carcinoma – Pheochromocytoma – Mucosal neuromas (oral/intestinal) – Marfanoid habitus We also explore MEN-like syndromes, such as: – Carney complex (cardiac myxomas, skin pigmentation, endocrine tumors) – Von Hippel-Lindau (VHL) disease – Neurofibromatosis type 1 (NF1) – McCune-Albright syndrome Key clinical pearls include: – Always screen for RET mutations in MTC before thyroidectomy – Rule out pheochromocytoma before surgery to avoid hypertensive crisis – In MEN1 patients, hyperparathyroidism is often the earliest and most frequent finding – Use calcitonin levels to monitor recurrence of medullary thyroid cancer This lecture is packed with mnemonics, clinical clues, and red flags to help you master gene mutations, tumor associations, and screening protocols — all crucial for cracking internal medicine questions on endocrine neoplasia in Step 2 CK and real clinical practice. 🎯 #MENsyndromes #MEN1 #MEN2A #MEN2B #RETmutation #ParathyroidTumor #Pheochromocytoma #MedullaryThyroidCancer #PancreaticNeuroendocrineTumors #USMLEStep2CK #InternalMedicineReview #HighYieldEndocrinology #WhiteboardMedicine #DrGBhanuPrakash #MedicalEducationUSA #Step2Prep #USMLEBuzzwords #NeuroendocrineTumors #NF1 #VHL #CarneyComplex #Calcitonin #USMLE2025 #MENlikeSyndromes #ConceptualMedicine #MedicalConcepts #NEETPGPrep #FMGE2025 #USMLE2025 #ClinicalMedicine #MBBSConcepts #NextExamPrep #MedSchoolMadeEasy #MedStudentLife #HighYieldMedicine #PathophysiologySimplified #LearnMedicineFast #VisualMedicine #MedicalMnemonics #CrackNEETPG #USMLEStep1Prep #MedEducationRevolution #MBBSShorts #DoctorInTheMaking
