Liver Function Test (LFT) Interpretation Made Easy | ALT, AST, ALP, GGT Explained

Liver Function Tests (LFTs) are one of the most commonly ordered investigations in clinical practice—but here’s the truth: they don’t actually measure liver “function” directly. Instead, they act as biochemical signals of liver injury, and understanding their patterns is the key to accurate diagnosis. In this video, we break down Liver Function Test Interpretation in the simplest and most clinically useful way, so you can confidently analyze any LFT report in exams and real-life practice. 🔍 What you’ll learn in this video: Why LFTs are actually damage indicators, not pure function tests How to identify hepatocellular, cholestatic, and mixed patterns Step-by-step interpretation of: ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) AST/ALT Ratio (with clinical significance) Alkaline Phosphatase (ALP) Gamma-Glutamyl Transferase (GGT) Bilirubin (Total, Direct, Indirect) How to differentiate liver vs non-liver causes of enzyme elevation Understanding albumin, globulin, and prothrombin time How to detect chronic vs acute liver disease using lab patterns 💡 You’ll also learn high-yield clinical correlations like: Why ALT is higher in viral hepatitis Why AST rises in advanced liver disease When AST/ALT ratio more than 2 suggests alcoholic liver disease How GGT helps confirm hepatobiliary origin Timestamp- 0:00 - Intro 3:21 - Hepatocyte Pattern 7:22 - Alanine Transaminase (ALT) 9:49 - Aspartate Aminotransferase (AST) 11:43 - AST/ALT Ratio 13:13 - Cholestatic Pattern (Alkaline Phosphatase) 15:46 - Gamma-glutamyl transferase (GGT) 20:11 - 5' Nucleotidase 21:52 - Synthetic Function (Albumin) 24:03 - Prothrombin Time 27:08 - Globulin & Albumin/Globulin ratio This video is perfect for: 📚 MBBS students 📚 NEET PG / INI-CET aspirants 📚 USMLE preparation 👨‍⚕️ Interns and clinicians ⚠️ Important Insight: LFT interpretation is not about memorizing values—it’s about recognizing patterns and understanding what the liver is trying to tell you. 🔥 If you found this helpful: 👍 Like the video 💬 Comment your doubts or clinical cases 🔔 Subscribe to Whiteboard Medicine Simplified for daily high-yield medical content 📌 Watch Next: 👉 Bilirubin Metabolism & Jaundice Explained (Complete Guide) #LFTInterpretation #LiverFunctionTest #ALTAST #MedicalEducation #NEETPG #USMLE #WhiteboardMedicine