Quick Pick 10/1/16 Clemson Tigers (-2) vs Louisville Cardinals Expert Prediction

Louisville meets Clemson in a matchup of two of the premier quarterbacks in the nation in Lamar Jackson for Louisville, and Deshaun Watson from Clemson. Jackson has been nothing short of sensational this season. Last week, threw for 417 yards in a 59-28 win for Louisville over Marshall. Jackson now has passed for over 1,300 yards with 13 TDs and he's also rushed for 12 TDs. Clemson is coming off an impressive 26-7 win over Georgia Tech last Thursday. Watson completed 32 of 48 for 304 yards with two TDs and a pick. The Tigers have struggled in the running game, which has hampered their offense. Their defense has allowed just 11 points per game, but they were be severely tested in this ACC matchup.