Every year, thousands of patients across the United States are impacted by the effects of hospital-onset Clostridioides difficile (C. diff) infections (HO-CDIs). With infections estimated at half a million per year, and health care costs amounting to $5.4 billion in excess, health systems are in critical need of more effective solutions to reduce HO-CDIs than are currently being employed. In a recent study, “Mitigating hospital-onset Clostridioides difficile: The impact of an optimized environmental hygiene program in eight hospitals,” researchers achieved a sustained 50% decrease in HO-CDIs across eight Trinity Health hospitals. This was the first-ever controlled study of a single type of intervention—in this case, optimized environmental hygiene—to decrease the transmission of C. diff. The intervention consisted of a standardized cleaning process, training, objective CDC approved cleaning monitoring and feedback to staff on cleaning thoroughness, in order to reduce infections. In this webinar, we examine the limitations of current interventions to prevent transmission of C. diff. We then explore the results of the study and other relevant published studies. Finally, we present the manner in which an effective environmental hygiene program to reduce HO-CDI is implemented and the critical role EVS personnel played.