Disease and illnesses have plagued humanity since the earliest days. However, it was not until the marked shift to agrarian communities that the scale and spread of these diseases increased dramatically. The more civilized humans became - with larger cities, more exotic trade routes, and increased contact with different populations of people, animals and ecosystems - the more likely pandemics would occur. Some major pandemics that have occurred over time: Antonine Plague 165 - 180 Cyprian Plague 250 A.D. Plague of Justinian 541 - 542 Black Death 1347 - 1351 The Great Plague of London 1665 Cholera Pandemics 1 -6) 1817 - 1923 The 3rd Plague Pandemic 1885 Fiji Measles Pandemic 1875 Russian Flu 1889 - 1890 Spanish Flu 1918 - 1919 Asian Flu 1957 - 1958 HIV/AIDS 1981 - PRESENT SARS 2002 - 2003 COVID-19 2019 - PRESENT