Recent emergence of the SARS-CoV-2 variant as OMICRON has become a global concern. World Health Organization (WHO) designated the variant B.1.1.529 named Omicron as a variant of concern (VOC) on the 26th of November 2021. The detection of mutations in the RBD region of Spike protein is a concern by surpassing vaccine immunity. This video is about its transmission potentiality, infectivity, and disease morbidity.