Sexual Differentiation Explained (In Hindi Podcast) #medicalpodcast #SexualDifferentiation #Embryo

🧬 Sexual Differentiation Made Easy | Male & Female Embryology Explained Welcome to this high-yield medical concept where we decode how a single undifferentiated gonad transforms into either testes or ovaries, shaping the internal and external genitalia of a developing embryo! 🌟 In this video, you’ll learn how chromosomal sex (XX or XY) triggers hormonal cascades that determine whether the embryo develops male or female sexual characteristics. We’ll explore the roles of the SRY gene, Sertoli cells, Leydig cells, Müllerian Inhibitory Factor (MIF), Testosterone, DHT, and Estrogen — all through clear diagrams and logical flowcharts! --- 🧠 What You’ll Learn in This Video 🔹 How SRY gene on the Y chromosome drives testis formation. 🔹 Role of Sertoli cells in secreting Müllerian Inhibitory Factor (MIF) — preventing female internal duct development. 🔹 Role of Leydig cells in producing Testosterone, which stimulates the Wolffian duct → forming internal male genitalia (Seminal vesicles, Epididymis, Ejaculatory duct, Ductus deferens). 🔹 Conversion of Testosterone to DHT (by 5α-reductase) → development of external male genitalia (Penis, Scrotum, Prostate). 🔹 How absence of MIF and androgens leads to female internal & external genitalia development. 🔹 Clinical concepts: 5α-reductase deficiency → ambiguous genitalia until puberty. Sertoli cell dysfunction → both male & female internal ducts present (mixed structures). 🔹 Secondary sexual characteristics and hormonal influences at puberty. --- 💡 Why You Should Watch This Video ✅ Perfect for MBBS, USMLE Step 1, NEET PG, PLAB, INICET, and other medical exams. ✅ Combines embryology + endocrinology + pathology for a complete conceptual understanding. ✅ Includes clinical correlations, mnemonics, and clear flow diagrams to make complex topics simple. ✅ Boost your concept retention and exam performance with visual learning! --- ⚕️ Key Concepts Simplified Leydig = Leads to male (internal & external) development Sertoli = Shuts down female internal ducts MIF (AMH) → suppresses Müllerian duct Testosterone → internal male genitalia DHT (via 5α-reductase) → external male genitalia Estrogen → female internal + external genitalia #SexualDifferentiation #Embryology #GenitalDevelopment #MedicalEducation #USMLE #NEETPG #MBBS #AnatomyLecture #Physiology #MIF #LeydigCells #SertoliCells #SRYGene #Testosterone #DHT #5AlphaReductase #MRKHSyndrome #MedStudentLife #BiologySimplified #ReproductiveSystem #HumanDevelopment #ClinicalEmbryology --- Sexual differentiation explained Male and female embryology SRY gene and testis determination Müllerian and Wolffian ducts Leydig and Sertoli cell function Müllerian Inhibitory Factor MIF AMH Testosterone and DHT function 5 alpha reductase deficiency Embryology of reproductive system Male internal and external genital development Female internal and external genital development Human sexual differentiation pathway USMLE embryology lecture NEET PG high yield embryology Clinical embryology concepts simplified