Lecture On Megaloblastic Anemia: Causes, Pathophysiology (Folate Trap), & Treatment | MBBS | TSMC

This comprehensive MBBS lecture by Dr. Swapan Sarkar from Tripura Santiniketan Medical College provides an in-depth analysis of Megaloblastic Anemia (MA), covering its heterogeneous causes, core pathophysiology, clinical manifestations, and critical treatment protocols. This video is an essential resource for medical students, residents, and practitioners studying Hematology and Internal Medicine. Dr. Sarkar focuses heavily on the two main culprits: Vitamin B12 (Cobalamin) and Folic Acid (Folate) deficiency, explaining how they impair DNA synthesis, leading to the characteristic asynchronous maturation of the nucleus and cytoplasm. Learn the vital mechanism of the "Folate Trap" and how it causes metabolic deprivation, even when folate levels appear sufficient. 📖 Table of Contents (Clickable Timestamps) [00:07] Pathophysiology: Impaired DNA Synthesis & Asynchronous Maturation [00:39] Primary Deficiencies: Cobalamin (B12) & Folate [01:37] Drugs Associated with MA (e.g., Hydroxyurea, Chemotherapy, Metformin) [01:59] Folic Acid Deficiency: Dietary Sources, Daily Requirements, and Malabsorption Causes (Celiac Disease, Topical Sprue) [03:46] Vitamin B12: Dietary Sources & Absorption via Intrinsic Factor [04:47] Common Causes of B12 Deficiency: Pernicious Anemia (Autoimmune), Gastrectomy, Ileal Resection [08:46] Pathophysiology of the Folate Trap and its Metabolic Consequences [12:09] Peripheral Blood Smear Features: Hypersegmented Neutrophils (Pathognomonic), Macrocytes, Poikilocytosis [13:25] Clinical Presentation (Weakness, Palpitations, Glossitis/Hunteritis) [13:59] Crucial Neurological Manifestations of B12 Deficiency (e.g., Subacute Combined Degeneration of the Spinal Cord) [14:37] Autoimmune Diseases Associated with Pernicious Anemia (Thyroiditis, Type 1 Diabetes Mellitus, Vitiligo) [15:24] Treatment Protocol for B12 Deficiency (Intramuscular Hydroxocobalamin) [16:32] Treatment Protocol for Folic Acid Deficiency Speaker: Dr. Swapan Sarkar Channel: Tripura Santiniketan Medical College 🏷️ Hashtags #MegaloblasticAnemia #VitaminB12Deficiency #FolicAcidDeficiency #HematologyLecture #Pathophysiology #PerniciousAnemia #FolateTrap #HypersegmentedNeutrophils #SubacuteCombinedDegeneration #MBBSLecture #InternalMedicine #MedicalEducation TRIPURA SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/ MEDICINE LECTURE ON-MEGALOBLASTIC ANEMIA BY-DR- SWAPAN SARKAR (MBBS Batch: 2024-25) Conducted on: 20-11-25 #mbbsclass #medical #class #education #mbbs #TSMC #students #everyoneシ゚viralシviralシfypシ゚viralシalシ #flowers #tripurasantiniketanmedicalcollege