ERCC Webinar: Loading cancer drones:  the regulation of exosomal non-coding RNA content by p53

George Calin from the MD Anderson Cancer Center presents his lab's work studying the regulation of non-coding RNA in cancer. This web seminar was presented as part of the Extracellular RNA Communication Consortium (ERCC) seminar series on 01 December, 2016. This presentation outlines the early phase of research by Dr. Calin and colleagues that led to a new discovery, that oral cancer cells can reprogram the fate of nerve cells in the mouth to make them more supportive of tumor growth. MicroRNA-trafficking EVs from the cancer cells mediate the change in nerve cell fate. For more details, see their article from the cover of Nature: Amit M et al. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature (2020) 578: 449-454. doi: https://doi.org/10.1038/s41586-020-19... Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/3...