Hypertension Pathophysiology| Renal, RAAS, SNS, Vascular Remodeling | Applied Pharmacology(Part 2)

In this video, we cover Hypertension – Part 2, focusing on the complete pathophysiology of systemic hypertension with clear applied clinical and pharmacological correlations. This lecture explains how blood pressure is regulated and how long-term alterations in: Renal sodium handling & pressure-natriuresis RAAS activation Sympathetic nervous system overactivity Vascular remodeling and arterial stiffness Genetic & monogenic causes lead to chronic hypertension, target-organ damage, and guide rational antihypertensive drug selection. 🔹 Ideal for MBBS, MD, DM, nursing exams, and clinicians wanting conceptual clarity. ------------------------------------------ Timestamps; 00:00 Intro 00:46 Determinants of Blood pressure 04:18 Role of (1)Intravascular volume and Renal sodium handling 04:24 Pressure-Natriuresis mechanism and it's alteration in HTN 05:58 Effect of Chronic high salt intake and body's response(autoregulation) 08:56 Applied aspect and drugs 11:20 Role of (2) Renin-Angiotensin-Aldosterone system(RAAS) 15:53 Reason for stopping ACEi and ARBs temporarily in volume loss states 17:06 Applied aspect and drugs 21:54 Role of (3) Autonomic Nervous system and Sympathetic hyperactivity 22:56 Role of baroreceptors in HTN 25:00 Role of alpha-1 and 2 receptors 27:02 image explaination of (3) 29:15 Applied aspect and drugs 30:15 (4) Vascular remodeling and Arteial stiffness 32:08 Role of small arteries(resistance vessels) 34:00 Role of Large arteries(Conduit vessels) and loss of windkessel effect 36:51 Applied aspect and drugs 37:00 Role of (5) Genetics and epigenetics 38:04 Monogenic HTN 38:37 Liddles syndrome #Hypertension #HypertensionPathophysiology #BloodPressureRegulation #RAAS #PressureNatriuresis #RenalPhysiology #SympatheticNervousSystem #VascularRemodeling #ArterialStiffness #AntihypertensiveDrugs #LiddlesSyndrome #MedicineLectures #Cardiology #Nephrology #MBBS #MDMedicine