"Once in a Lifetime" is a song by the American band "Talking Heads", produced and cowritten by Brian Eno. From Talking Heads' fourth studio album, "Remain in Light" (1980), through Sire Records. "Eno" and "Talking Heads" developed "Once in a Lifetime" through extensive jams, inspired by Afrobeat musicians such as Fela Kuti. David Byrne's vocals were inspired by preachers delivering sermons, with lyrics addressing existential crisis and the unconscious. The music video, directed by Byrne and Toni Basil, has Byrne dancing erratically over footage of religious rituals.