Lecture On Water Soluble Vitamins B6 & B9 - Metabolism, Deficiency, & Clinical Correlation | MBBS

Master the complex biochemistry of Water Soluble Vitamins with this in-depth lecture by Dr. Sagar Majumder from the Tripura Santiniketan Medical College (TSMC). This video provides an essential overview of Pyridoxine (Vitamin B6), Folic Acid (Vitamin B9), and includes an introduction to Cobalamin (Vitamin B12), focusing on their active forms, key metabolic reactions, deficiency manifestations, and crucial clinical correlations. This lecture is a must-watch for MBBS students, medical aspirants, and anyone studying Biochemistry or Nutrition. VIDEO CHAPTERS (Use these timestamps to navigate the lecture): Part 1: Pyridoxine (Vitamin B6) [00:00] Introduction to Pyridoxine (B6) & Active Form: PLP (Pyridoxal Phosphate) [00:43] B6 as the Vitamin of Amino Acid Metabolism (Transamination, Decarboxylation). [03:37] Detailed Explanation of Transamination Reaction (ALT, AST). [07:58] Decarboxylation & Synthesis of Biogenic Amines (Serotonin, Histamine). [09:41] Role in Hemoglobin (Heme) Synthesis (Condensation Reaction). [10:07] Role in Tryptophan Metabolism & Niacin Synthesis. [12:38] Role in Methionine Metabolism & Homocysteinemia. [14:38] Role in Glycogenolysis (Glycogen Phosphorylase). [15:58] B6 Deficiency Manifestations (Neurological Symptoms, Convulsions, Peripheral Neuropathy). [17:17] Hypochromic Microcytic Anemia (Due to decreased Heme production). [18:23] Drug Interactions: Isoniazid and Penicillamine. [21:13] Pyridoxine-Responsive Sideroblastic Anemia (Iron Refractory Anemia). [22:01] B6 Toxicity (Sensory Neuropathy). Part 2: Folic Acid (Vitamin B9) [22:50] Folic Acid (B9): Hemopoietic Vitamin & Structure. [24:13] Active Form: Tetrahydrofolate (THF). [27:59] Role in One-Carbon Metabolism (Transfer of Carbon Units). [28:44] The Folate Trap Hypothesis (Interaction with B12). [34:18] Folic Acid Deficiency Consequences (DNA damage, Macrocytic Anemia). [34:53] Mechanism of Macrocytic/Megaloblastic Anemia. [38:03] Differentiating Folic Acid vs. Vitamin B12 Deficiency (Methylmalonic Acid test). [41:01] Neural Tube Defects (NTDs): Spina Bifida and Anencephaly (The importance of early pregnancy supplementation). [44:22] Folic Acid Antagonists (Methotrexate, Sulfonamides). Part 3: Cobalamin (Vitamin B12) Introduction [45:28] Introduction to Cobalamin (B12): The COBAMIN Acronym. [46:16] Requirement of Intrinsic Factor for Absorption. [50:49] Mechanism of B12 Absorption (Parietal Cells, Intrinsic Factor). [53:11] Metabolic Functions: Methionine Synthesis & Methylmalonyl CoA Mutase reaction. [56:04] B12 Deficiency Causes (Pernicious Anemia, Fish Tapeworm Infestation). [01:00:02] Deficiency Manifestation: Subacute Combined Degeneration (Demyelination). Call to Action & Hashtags Don't forget to Like this video and Subscribe to the Tripura Santiniketan Medical College channel for more high-quality medical lectures! #VitaminB6 #Pyridoxine #FolicAcid #VitaminB9 #BiochemistryLecture #MBBS #MedicalSchool #MegaloblasticAnemia #Homocysteinemia #VitaminDeficiency #PLP #BiogenicAmines Video Link:    • Lecture On Water Soluble Vitamins B6 & B9 ...   TRIPURA SANTINIKETAN MEDICAL COLLEGE Real Classroom Demonstration/Lecture BIOCHEMISTRY LECTURE ON- WATER SOLUBLE VITAMIN. BY-DR. SAGAR MAJUMDER (MBBS Batch: 2025-26) Conducted on: 04-11-25 #mbbsclass #medical #class #education #mbbs #TSMC #students #everyoneシ゚viralシviralシfypシ゚viralシalシ #flowers #tripurasantiniketanmedicalcollege salmonry. And what are the different types of proteins