Iran and Israel exchange airstrikes for third day after nuclear talks called off Iran and Israel exchange airstrikes for third day after nuclear talks called off Israel unleashed airstrikes across Iran for a third day on Sunday and threatened even greater force. Also Sunday, some Iranian missiles evaded Israel's air defenses to strike buildings in the heart of the country. The exchange of fire comes as talks on Iran's nuclear program in Oman between the U.S. and Iran were called off. The simultaneous strikes represented the latest salvo since a surprise attack by Israel three days earlier aimed at decimating Tehran's rapidly advancing nuclear program. Iran said Israel struck two oil refineries, raising the prospect of a broader assault on Iran's heavily sanctioned energy industry that could affect global markets. The Israeli military, in a social media post, warned Iranians to evacuate arms factories, signaling what could be a further widening of the campaign. Around noon local time, explosions were heard again in the Iranian capital, Tehran. Iranian Foreign Minister Abbas Araghchi said Sunday that if the Israeli strikes on Iran stop, then "our responses will also stop." He said the United States "is a partner in these attacks and must take responsibility." New explosions echoed across Tehran and were reported elsewhere in the country early Sunday. The Washington-based Human Rights Activists group said Sunday that the Israeli strikes in Iran have killed at least 406 people and wounded another 654. The group was working to identify who among the casualties were civilians and who were part of the security services. Iran's government has not offered overall casualty figures as it struggles with the strikes that have decimated its military leadership and targeted its nuclear sites. Individual officials have offered partial figures. On Saturday, Iran's U.N. ambassador said 78 people had been killed and more than 320 wounded. In Israel, at least 10 people were killed in Iranian strikes overnight and into Sunday, according to Israel's Magen David Adom rescue service. It brought the country's total death toll to 13, including a 10-year-old and a 9-year-old in Bat Yam, near Tel Aviv, since the strikes began on Friday night. Iran has fired over 270 missiles, 22 of which made impact, according to official Israeli figures. Israeli strikes targeted Iran's Defense Ministry early Sunday after hitting air defenses, military bases and sites associated with its nuclear program. The killing of several top generals and nuclear scientists in targeted strikes indicated that Israeli intelligence has penetrated Iran at the highest levels. Israel — widely believed to be the only nuclear-armed state in the Middle East — has sophisticated multi-tiered air defenses that are able to detect and intercept missiles fired at populated areas or key infrastructure, but officials acknowledge it is imperfect. Israel's defense minister warned Saturday that "Tehran will burn" if Iran continues firing missiles at Israel. Speaking after an assessment meeting with the army's chief of staff, Defense Minister Israel Katz said Iran will pay a heavy price for harming Israeli citizens. At least three people have died in Israel, and dozens were wounded, Israel Defense Forces officials said Saturday morning. "If (Iranian Supreme Leader Ayatollah Ali) Khamenei continues to fire missiles at the Israeli home front — Tehran will burn," Katz said. Following Israel's expanded assault, Katz followed up early Sunday morning with a post that read, "Tehran is burning. Urgent calls to de-escalate Prime Minister Benjamin Netanyahu, who has made the destruction of Iran's nuclear program his top priority, brushed off urgent calls from world leaders to de-escalate, saying Israel's strikes so far are "nothing compared to what they will feel under the sway of our forces in the coming days." Israel's initial assault used warplanes — as well as drones smuggled into the country in advance, according to officials — to hit key facilities and kill top generals and scientists. "The individuals who were eliminated played a central part of the progress toward nuclear weapons," the IDF said in a news release. "Their elimination represents a significant blow to the Iranian regime's ability to acquire weapons of mass destruction." Iran retaliated by launching waves of drones and ballistic missiles at Israel, where explosions lit the night skies over Jerusalem and Tel Aviv and shook the buildings below. The Israeli military urged civilians, already rattled by 20 months of war in Gaza sparked by Hamas' Oct. 7 attack, to head to shelter for hours. U.S. officials confirmed to CBS News that U.S. forces helped Israel intercept Iranian missiles on Friday.