Easiest Way to Kill a Big Sister

DRILL HER Big Sisters can be extremely difficult opponents, but using this simple, obvious, and "too good to be true" technique makes short work of them every time. The trick is to use the drill... Get in her face and overwhelm her using the drill spin, and electro bolt works well to freeze her, or winter blast can be used. Make sure you have at least a half tank of drill fuel beforehand, though it may take 3/4 to a full tank to kill her. The "Freezing Drill" Gene Tonic is a nice added touch but not necessary. And it helps to have Gene Tonics like "Drill Power" and "Drill Lurker" as well. You should probably have at least 2 EVEs and First Aid Kits and be prepared to heal at least once or twice as she will still hurt you during your drilling assault. As usual, the clip is on the hardest difficulty setting available, in this case called "Hard".