Cobenfy (KarXT): A new miracle drug for schizophrenia?

Much like the rest of the schizophrenia community, I have been excited about the development of a new type of antipsychotic that is now available by the name of Cobenfy (previously KarXT). I think though that what is exciting about this is getting a little bit confused. I dive more into this and the latest study findings around efficacy of Cobenfy - and what this means for patients living with schizophrenia who may be interested in trying it. Timestamps: 00:00 - New "game changing" drug for schizophrenia? 01:20 - Background and development of Cobenfy (KarXT) 03:10 - Antipsychotic targeting different receptors - a breakthrough! 04:26 - Digging into October 31, 2024 press release on latest results from Emergent-4 and Emergent-5 trials from Bristol Myers Squibb (Surprising and maybe disappointing results!) 10:06 - Comparing Cobenfy trial to other trials on currently used antipsychotics 12:40 - Comparing to placebo 14:30 - Side effects 16:45 - Qualitative reportings don't make sense to me... 18:38 - Who might Cobenfy be best for? 20:06 - I'm not tearing Cobenfy apart! but... 21:25 - I get the appeal of a "revolutionary" treatment for schizophrenia 22:35 - Cost 23:46 - Conclusion (an exciting start! but not game changing in itself) References: Bristol Meyer Squibb Press Releases on Cobenfy Emergent-4 and Emergent-5 Trials: October 31, 2024 - https://news.bms.com/news/corporate-f... September 26, 2024 - https://news.bms.com/news/details/202... Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors: https://psychiatryonline.org/doi/full... Clozapine Response Rates among People with Treatment-Resistant Schizophrenia: Data from a Systematic Review and Meta-Analysis: https://pmc.ncbi.nlm.nih.gov/articles... How Efficacious Are Antipsychotic Drugs for Schizophrenia? An Interpretation Based on 13 Effect Size Indices: https://pmc.ncbi.nlm.nih.gov/articles... Revolutionary drug for schizophrenia wins US approval: https://www.nature.com/articles/d4158... A “Game-Changing” New Drug for Schizophrenia?: https://www.bu.edu/articles/2024/a-ga... FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia: https://www.fda.gov/news-events/press... A promising schizophrenia drug showed mixed results. What does that mean for patients?: https://apnews.com/article/schizophre... Karuna Therapeutics surges 47% after Bristol Myers Squibb announces $14 billion deal: https://www.cnbc.com/2023/12/22/brist... FDA approves new drug for treatment of schizophrenia:    • FDA approves new drug for treatment of sch...   Karuna Therapeutics CEO discusses the biotech firm's drug trials for schizophrenia:    • Karuna Therapeutics CEO discusses the biot...   Karuna Therapeutics soars on potentially 'game changing' new schizophrenia drug:    • Karuna Therapeutics soars on potentially '...   MEDICAL KETO RESOURCES You can learn more about medical keto for mental illnesses on the Metabolic Mind YouTube channel (@metabolicmind) and on their website https://www.metabolicmind.org/ You can find more about my keto coach Nicole Laurent and her work on her website: https://www.mentalhealthketo.com/ You can also learn more about metabolic health and mental illness from the book 'Brain Energy' by Dr. Christopher Palmer - https://brainenergy.com/ JOIN OUR COMMUNITIES Join a free online community of people using metabolic therapies to treat their mental illness. • Metabolic Therapies for Mental Disorders: https://www.metabolictherapysupport.com/ We also have a peer support community specifically for people living with psychosis spectrum illnesses. • Schizophrenia Peer Support Community: https://www.schizophreniapeersupport.com SPEAKING & CONSULTING Looking for an expert speaker or consultant for your upcoming event or project? With years of experience and a passion for mental health advocacy, I can provide the insight and inspiration you need to make a positive impact. Visit my speaking website to learn more! https://www.laurenkennedywest.com/ SOCIALS Instagram:   / livingwellwithschizophrenia   TikTok:   / livingwellschizophrenia   Twitter:   / lwschizophrenia