Since the death of Fortinbras by the hands of Samanosuke, Nobunaga Oda has taken command of the Genma as he continues his campaign to unite Japan while wiping out any threat to his power. Among the villages he targeted is the Yagyu village. The clan's only survivor, Jubei Yagyu, who was away at the time of the Genma attack, finds the destroyed village and goes to search for the culprit. He encounters a female oni named Takajo who explains Nobunaga's actions. Revealing herself as Jubei's mother, Takajo unleashes Jubei's Oni powers and tells him to search for five orbs that were created to protect humans from demons. Jubei then embarks on a quest to find the orbs in order to defeat Nobunaga, first traveling to the mining town of Imasho.