Resident Evil 4 Village Strat PRO

You kill the first ganado and run into the house right after. Turn left and throw the first grenade outside the small hole. Turn around and wait for the cutscene, skip it and walk upstairs. I walk upstairs slowly cause it gives the enemies time to group in front of the window. After I grab the shotgun I start running again. Grab the grenade and run to the window, throw the grenade outside. Try aiming a bit to the right and also very far down, so you also hit the enemies on the right side of the house. This strategy is not super consistent, but it saves around 5 seconds over the old one. All credits go to Ayi -R!