4 Signs of Low Progesterone That Are Often Overlooked 1. Heightened anxiety or mood swings before your period — Progesterone has a calming effect on the brain. When levels drop too low in the second half of your cycle, it can trigger irritability, anxiety, or feeling emotionally overwhelmed. 2. Fibrocystic or tender breasts — Progesterone helps balance the effects of estrogen on breast tissue. When it’s low, estrogen can overstimulate the tissue, leading to lumpiness, swelling, or breast tenderness—especially before your period. 3. Mid-cycle spotting or short cycles — Progesterone is produced after ovulation. If levels are too low, it can lead to spotting, a shortened luteal phase, or missed periods altogether. 4. Infertility or trouble maintaining pregnancy Progesterone prepares the uterine lining for implantation and supports early pregnancy. Low levels can interfere with both. #hormones #lowprogesterone #hormoneimbalance