Lecture On Repair Pathology: Regeneration, Granulation Tissue & Fracture Healing | MBBS

In this session, we break down the complex biological processes the body uses to restore structural integrity after injury. We explore the critical differences between regeneration and repair, the hallmark role of granulation tissue, and the clinical nuances of healing by primary and secondary intention. 📘 Key Learning Objectives: Cellular Foundations: Classification of tissues into Labile, Stable, and Permanent based on proliferative capacity [07:42]. The Repair Process: Understanding how the body "patches" defects through fibrosis and scar formation [12:44]. Granulation Tissue: Why it is the "hallmark of healing" and how to differentiate it from a Granuloma [15:05]. Primary vs. Secondary Intention: Detailed comparison of healing in clean surgical wounds vs. large, infected defects [24:02]. Fracture Healing: Step-by-step analysis from pro-callus formation to bony remodeling [33:34]. Clinical Factors: How age, nutrition (Vitamin C), steroids, and diabetes influence the rate of recovery [31:47]. Detailed Timestamps: [00:00] - Introduction to Repair, Regeneration, and Healing [03:39] - Regeneration vs. Repair (Scaffolding vs. Patching) [07:50] - Labile, Permanent, and Stable Tissues [11:07] - Mechanism of Liver Regeneration [14:51] - Granulation Tissue: Gross & Microscopic Features [17:33] - Components of Connective Tissue Repair (Angiogenesis) [19:54] - Abnormalities in Tissue Repair (Keloids & Hypertrophic Scars) [21:33] - Role of TGF-Beta in Fibrosis [24:02] - Healing by First Intention (Primary Union) [29:48] - Healing by Second Intention (Secondary Union) [33:34] - Fracture Healing Stages (Pro-callus to Lamellar Bone) [38:40] - Complications of Fracture Healing (Pseudoarthrosis) SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PATHOLOGY by Dr. Lahari Banik (MBBS Batch: 2024-25) Conducted on: 17-12-25