Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. Author Ayalew Tefferi, MD, of the Mayo Clinic, joins JAMA Associate Editor David Simel, MD, MHS, to discuss diagnosis and treatment of this condition. Related Content: Essential Thrombocythemia https://jamanetwork.com/journals/jama... Podcast was originally published on January 27, 2025. https://edhub.ama-assn.org/jn-learnin... --------------------------------------------------------------------------------- Follow JAMA Clinical Reviews on: Youtube: • JAMA Clinical Reviews Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/229VuDi... Pocket Casts: https://pca.st/3ghw Your podcast app of choice: https://pod.link/1027430378 Website: https://jamanetwork.com/journals/jama... --------------------------------------------------------------------------------- For more from JAMA • https://www.jama.com • / jamajournal • / jama_current • / jamanetwork Follow the JAMA Network • https://www.jamanetwork.com • http://www.jamanetworkaudio.com • / jamanetwork • / jamanetwork • / jamanetwork • / jamanetwork