Lecture On Pediatric Tuberculosis (TB): Pathogenesis, Diagnosis & Drug Resistance | MBBS

This class provides a comprehensive overview of Pediatric Tuberculosis (TB), covering its unique pathogenesis, clinical features in children, modern diagnostic tests (like CBNAAT/GeneXpert), and the latest NTEP (National Tuberculosis Elimination Program) treatment guidelines. This is essential content for medical students preparing for their professional exams and clinical rotations. LECTURE HIGHLIGHTS (TIMESTAMPS): [03:14] Pathogenesis of TB: Ghon Focus and Primary Complex [05:48] Understanding Progressive Primary Disease (PPD) and Cavitation [06:51] Hematogenous Spread: TB affecting any organ of the body (Except hair and nails) [08:59] General Clinical Suspicion Criteria [12:19] Extra-Pulmonary TB: Lymphadenitis, Abdominal TB, Spinal TB (Gibbus deformity) [16:50] CNS TB: Signs of Meningeal Irritation (Neck Rigidity, Brudzinski's, Kernig's sign) [19:04] Screening and Contact History (Crucial duration: within the last 2 years) [21:10] Tests for Latent TB: Tuberculin Test (Mantoux) vs. IGRA (Interferon Gamma Release Assay) [25:37] Sample Collection in Children: Gastric Aspirate and Induced Sputum [25:52] Modern Diagnosis: CBNAAT (GeneXpert) for TB DNA detection & Resistance [30:10] NTEP (Formerly RNTCP) Treatment Regimen (2HRZE/4HR) [31:07] Key Drug Toxicities (Ethambutol: Retrobulbar Optic Neuritis) [32:00] Specific Indications for Steroid Use in TB (TBM, Pericardial TB, Airway Obstruction) [34:40] INH Prophylaxis for High-Risk Child Contacts [37:37] Drug-Resistant TB: Diagnosis and Suspected Cases [39:56] Definitions: MDR-TB (Resistance to H&R) and XDR-TB SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PAEDIATRICS by Dr. Nandan Rudra (MBBS Batch: 2021-22) Conducted on: 26-11-25