Like-Subscribe- Push notification bell for helping our channel Interesting diseases playlist: • INTERESTING CONDITIONS, Medical videos, In... Blue man syndrome case report: https://www.ncbi.nlm.nih.gov/pmc/arti... What is blue man syndrome? Blue man syndrome, also known as argyria, can occur from long-term amiodarone use however was initially seen in silver toxicity. Significant bluish discoloration of the skin can is seen. Discontinuing amiodarone therapy frequently improves the discoloration. What causes blueman syndrome? Blue man syndrome is thought to stem from the deposition of lysosomal membrane-bound dense bodies, similar to lipofuscin, in the dermis of patients on chronic amiodarone therapy. What happened to the man who turned blue? A man who turned blue after taking silver for a skin condition has died. Paul Karason, 62, suffered a heart attack before contracting pneumonia and having a severe stroke Why does amiodarone cause blue skin? The presence of amiodarone deposits in the skin, with or without lipofuscin, is able to induce the blue-gray hyperpigmentation. Is blue skin possible? Argyria is a rare skin condition that can happen if silver builds up in your body over a long time. It can turn your skin, eyes, internal organs, nails, and gums a blue-gray color, especially in areas of your body exposed to sunlight