Multiple Sclerosis "Rebound" [After Stopping Medication]

Sometimes people with MS can get dramatically worse after stopping certain types of disease modifying therapies known as immunosequestrants (such as Tysabri, gilenya, mayzent, zeposia). This video discusses the phenomenon of “rebound” disease activity and reviews the risk factors and treatment references: Fingolimod Rebound: A Review of the Clinical Experience and Management Considerations: https://www.ncbi.nlm.nih.gov/pmc/arti... Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab therapy: https://pubmed.ncbi.nlm.nih.gov/20937... Neurological safety of fingolimod: An updated review: https://pubmed.ncbi.nlm.nih.gov/28932... Rebound exacerbation multiple sclerosis following cessation of oral treatment: https://pubmed.ncbi.nlm.nih.gov/25877... Severe tumefactive rebound of multiple sclerosis following fingolimod cessation: https://casereports.bmj.com/content/2... Factors associated with fingolimod rebound: A single center real-life experience: https://www.sciencedirect.com/science... Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: https://amazon.com/dp/B07WP7H5LK It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty. Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter:   / brandon_beaber   Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link:    • Video   T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.