Urea: Clinical significance (RFTs)

Urea is a waste product of protein metabolism that is excreted in the urine. Its clinical significance can be evaluated by measuring the blood urea nitrogen (BUN) level. Elevated BUN levels can be an indicator of kidney dysfunction or dehydration, while low levels may indicate liver disease or malabsorption. An increase in BUN levels may also be seen in conditions such as heart failure, burns, and sepsis, in which there is an increase in protein catabolism. A decrease in BUN levels may indicate malnutrition or an overactive thyroid. Urea is also used as an indicator of the renal function and the GFR (glomerular filtration rate) . A BUN level of 8-25 mg/dL is considered normal, but the normal range may vary depending on the lab and the population being studied. It is important to note that BUN can be affected by other factors such as protein intake, hydration status, and drugs. Therefore, BUN levels should be interpreted in conjunction with other laboratory tests and clinical findings. Urea is the metabolic product of the protein. It is synthesized in liver and kidneys from ammonia. It is less toxic and need less amount of water to be excreted from body by the kidneys. Clinically we measure its concentration in blood and urine to know the performance of kidneys that's why it is included in renal functions tests (RFTs). To learn further attend the lecture and ask question if any #shorts #tothepoint #RFTs .