Murphyâs Sign â Seen in acute cholecystitis (pain when pressing the right upper abdomen during inspiration). Kernigâs Sign â Suggests meningitis (pain on extending knee when hip is flexed). Brudzinskiâs Sign â Another meningitis sign (neck flexion causes hip and knee flexion). Chvostekâs Sign â Indicates hypocalcemia (facial muscle twitch when tapping facial nerve). Trousseauâs Sign â Also for hypocalcemia (carpal spasm after inflating BP cuff). Battleâs Sign â Basal skull fracture (bruising behind the ear). Grey Turnerâs Sign â Retroperitoneal hemorrhage or pancreatitis (flank bruising). Cullenâs Sign â Acute pancreatitis (periumbilical bluish discoloration). Clubbing â Seen in chronic lung disease, cyanotic heart disease, liver cirrhosis. Koilonychia â Iron deficiency anemia (spoon-shaped nails).