On May 16, devil hunter Nero hunts a demon named Urizen after a dying man in a cloak steals his right arm and the Yamato sword. Traveling to Red Grave City, he joins Dante and finds a demonic tree called Qliphoth planted in the city, which is killing people for their blood. Dante is ultimately defeated and ejected from the Qliphoth with his sword Rebellion shattered. His allies Lady and Trish are captured to use as demon-cores, and a client of Dante, V, convinces the weakened Nero to escape. On June 15, Nero returns to Red Grave outfitted with the "Devil Breaker" prosthetic arm, made by his friend Nico. Nero meets up with V, who is seeking Qliphoth for its fruit, born of condensed human blood, which makes whomever consumes it the king of the Underworld…